Neuromonitoring-guided working memory intervention in children with ADHD.

Neuromonitoring-guided working memory intervention in children with ADHD. iScience Rahimpour Jounghani, A., Gozdas, E., Dacorro, L., Avelar-Pereira, B., Reitmaier, S., Fingerhut, H., Hong, D. S., Elliott, G., Hardan, A. Y., Hinshaw, S. P., Hosseini, S. M. 2024; 27 (11): 111087

Abstract

We proposed a personalized intervention that integrates computerized working memory (WM) training with real-time functional neuromonitoring and neurofeedback (NFB) to enhance frontoparietal activity and improve cognitive and clinical outcomes in children with attention-deficit/hyperactivity disorder (ADHD). The study involved 77 children with ADHD aged 7-11 years, who were assigned to either 12 sessions of NFB or treatment-as-usual (i.e., received standard clinical care) groups. Real-time neuromonitoring with functional near-infrared spectroscopy (fNIRS) and fMRI measured frontoparietal activity during n-back task at baseline and post-intervention. Thirty-six participants (21 NFB, 15 treatment-as-usual) completed the study. Significant improvements in NFB group were observed in frontoparietal brain activity and WM performance (primary outcomes). NFB group also showed improvements in Behavior Rating Inventory of Executive Function (BRIEF-2) WM t-scores and Conners 3 ADHD index scores (secondary outcomes) compared to treatment-as-usual group. These findings suggest that neuromonitoring-guided NFB effectively enhances cognitive and clinical outcomes in children with ADHD by targeting brain mechanisms underlying WM deficits.

View details for DOI 10.1016/j.isci.2024.111087

View details for PubMedID 39493886

View details for PubMedCentralID PMC11530911