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The impact of sex and body mass index in liver transplantation for acute-on-chronic liver failure.

The impact of sex and body mass index in liver transplantation for acute-on-chronic liver failure. Journal of hepato-biliary-pancreatic sciences Akabane, M., Imaoka, Y., Nakayama, T., Esquivel, C. O., Sasaki, K. 2024

Abstract

There have been no studies evaluating how body mass index (BMI) impacts on waitlist and post-liver transplant (LT) mortality in acute-on-chronic liver failure (ACLF) by sex. We aimed to determine these impacts using the United Network for Organ Sharing (UNOS) database.Adults listed for LT with estimated ACLF (Est-ACLF) (2005-2023) were identified and subdivided by sex and BMI (high/middle/low). Competing-risk analyses evaluated impacts on waitlist mortality. Kaplan-Meier analyses assessed post-LT survival. Multivariable Cox regression identified risk factors.Of 37?251 Est-ACLF patients, 14?534 (39.0%) were female. Females had higher 90-day waitlist mortality than males (subhazard ratio [sHR]: 1.20, p?

View details for DOI 10.1002/jhbp.12100

View details for PubMedID 39727045