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MYOCARDIAL-INFARCTION - ASSESSMENT WITH AN INTRAVASCULAR MR CONTRAST-MEDIUM - WORK IN PROGRESS RADIOLOGY Saeed, M., Wendland, M. F., Masui, T., Connolly, A. J., Derugin, N., Brasch, R. C., Higgins, C. B. 1991; 180 (1): 153-160

Abstract

The effect of a new intravascular magnetic resonance (MR) contrast medium (gadolinium diethylenetriaminepentaacetic acid [DTPA] polylysine) was evaluated in acute, subacute, and chronic myocardial infarctions in rats. Signal intensity (SI) was measured before and after intravenous administration of Gd-DTPA polylysine. Before administration of contrast material, chronic infarctions had lower SI than normal myocardium. With Gd-DTPA polylysine, three zones were identified in acute and subacute stages of myocardial infarction, but in the chronic stage, images demonstrated two zones. In acute and subacute infarctions, Gd-DTPA polylysine produced greater enhancement (over 60 minutes) in the peri-infarction zone than in the normal or infarcted myocardium. In chronic infarctions, Gd-DTPA polylysine had no discernible effect on the SI of the central infarction zone. Overall, it caused no significant hemodynamic effects. MR imaging with Gd-DTPA polylysine produced differential tissue enhancement in myocardial infarctions, which varied according to the age of the infarction.

View details for Web of Science ID A1991FR67900034

View details for PubMedID 2052685