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Lumpectomy surgery for large ductal carcinoma in situ.

Lumpectomy surgery for large ductal carcinoma in situ. Breast cancer research and treatment Padilla, D. B., Tsai, J., Beck, A. S., Wapnir, I. L. 2025

Abstract

PURPOSE: Breast-conserving surgery for larger ductal carcinoma in situ (DCIS) remains limited. We compare the attempted use and success rates of lumpectomy surgery in patients with DCIS measuring=4cm versus<4cm.METHODS: A retrospective review was conducted using the institutional tumor registry to identify cases of pure DCIS that were surgically treated from 2015 to 2022. Clinical-pathological data were abstracted from electronic medical records. Pathologic tumor size on initial surgery was used to define the two cohorts. Comparisons of variables were made using Chi-square and ANOVA tests.RESULTS: A total of 669 patients, 84% (562) with tumors measuring<4cm and 16% (107)=4cm were identified. Lumpectomy was the initial surgery performed for 89% of women with lesions measuring<4cm on preoperative imaging studies compared to 64% of those=4cm. Overall, 461 (92.9%) of 496 in the<4cm succeeded at lumpectomy compared to 36 (56.3%) of 64 in the=4cm group. Re-excision lumpectomies or mastectomy were performed in 27% and 44% of the<4cm and=4cm subgroups. Lumpectomy was achieved for 70% of women with tumors in the 4 to 5.9cm range compared to 33% in the 6-7.9cm and the=8cm groups. There were no local recurrences in the=4cm group at an average of 4.4years follow-up.CONCLUSION: Lumpectomy is a viable option for many patients with DCIS=4cm, especially those measuring<6cm, though repeat re-excisions may be required after initial attempt.

View details for DOI 10.1007/s10549-025-07621-w

View details for PubMedID 39928263