Skip to main content
 
Notice: Users may be experiencing issues with displaying some pages on stanfordhealthcare.org. We are working closely with our technical teams to resolve the issue as quickly as possible. Thank you for your patience.
Stanford Health Care

Osteopontin attenuates the foreign-body response to silicone implants.

Osteopontin attenuates the foreign-body response to silicone implants. Nature biomedical engineering Griffin, M. F., Parker, J. B., Tevlin, R., Liang, N. E., Valencia, C., Morgan, A., Kuhnert, M., Downer, M., Meany, E. L., Guo, J. L., Henn, D., Navarro, R. S., Shefren, K., Nguyen, D., Gurtner, G. C., Heilshorn, S. C., Chan, C. K., Januszyk, M., Appel, E. A., Momeni, A., Wan, D. C., Longaker, M. T. 2025

Abstract

The inflammatory process resulting in the fibrotic encapsulation of implants has been well studied. However, how acellular dermal matrix (ADM) used in breast reconstruction elicits an attenuated foreign-body response (FBR) remains unclear. Here, by leveraging single-cell RNA-sequencing and proteomic data from pairs of fibrotically encapsulated specimens (bare silicone and silicone wrapped with ADM) collected from individuals undergoing breast reconstruction, we show that high levels of the extracellular-matrix protein osteopontin are associated with the use of ADM as a silicone wrapping. In mice with osteopontin knocked out, FBR attenuation by ADM-coated implants was abrogated. In wild-type mice, the sustained release of recombinant osteopontin from a hydrogel placed adjacent to a silicone implant attenuated the FBR in the absence of ADM. Our findings suggest strategies for the further minimization of the FBR.

View details for DOI 10.1038/s41551-025-01361-4

View details for PubMedID 40128393

View details for PubMedCentralID 8081831