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Local Antibiotic Delivery in Orthopedics: Review of Current Practices and Emerging Technologies.

Local Antibiotic Delivery in Orthopedics: Review of Current Practices and Emerging Technologies. Infectious disease clinics of North America Aronson, J. R., Justo, J. A., Amanatullah, D. F. 2025

Abstract

This article explores the role of local antibiotic delivery in the management of orthopedic infections, a significant challenge in modern healthcare. This article delineates between prophylactic and therapeutic uses of antibiotics, examining various delivery methods, including topical powders, irrigation solutions, intraosseous injections, and antibiotic-loaded bone cement. While local administration aims to enhance therapeutic efficacy and minimize systemic exposure, there is limited evidence supporting effectiveness. The article aims to review the current practices and evidence and highlight emerging strategies such as hydrogels and biodegradable systems. Ongoing research is essential to optimize these methods and improve patient outcomes in orthopedic care.

View details for DOI 10.1016/j.idc.2025.03.002

View details for PubMedID 40410075