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Anti-tumor and radiosensitization activities of the iron chelator HDp44mT are mediated by effects on intracellular redox status CANCER LETTERS Tian, J., Peehl, D. M., Zheng, W., Knox, S. J. 2010; 298 (2): 231-237

Abstract

A novel iron chelator, HDp44mT, has been reported to have potent anti-proliferative effects on cancer cells; however, the underlying mechanism of action is not well understood. In this study, we characterized the cytotoxic effect of HDp44mT in a chemo- and radio-resistant cell line (PC-3) of prostatic cancer origin. The activity of HDp44mT at nM concentrations was dependent on the intracellular GSH and atmospheric O(2) concentration, rather than iron deprivation. HDp44mT also radiosensitized PC-3 cells in a GSH-dependent manner. Interestingly, this radiosensitizing effect was observed under aerobic and, to a larger extent, hypoxic conditions, suggesting its potential utility as a radiosensitizer for some radioresistant tumors.

View details for DOI 10.1016/j.canlet.2010.07.010

View details for Web of Science ID 000284300000011

View details for PubMedID 20678860