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Focused ultrasound-mediated drug delivery systems: a technological overview, possible musculoskeletal applications, and future directions.

Focused ultrasound-mediated drug delivery systems: a technological overview, possible musculoskeletal applications, and future directions. RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin Sassi, R., Gazzotti, S., Aparisi Gómez, M. P., Donati, C. M., Morganti, A. G., Weber, M. A., Ghanouni, P., Napoli, A., Bazzocchi, A. 2026

Abstract

Innovation in focused ultrasound (FUS) has led to new applications for treating musculoskeletal pathologies, including oncologic, infectious, and degenerative diseases. Focused ultrasound-mediated drug delivery is particularly interesting in fields in which high selectivity and localized action are needed to avoid unwanted side effects or therapy failure, for example with antineoplastic and antimicrobial drugs.For this paper, a literature search of the PubMed database was performed using the keywords "focused ultrasound" and "musculoskeletal applications".This review article presents an overview of the currently available technologies for focused ultrasound-mediated drug delivery and their possible musculoskeletal applications, along with a discussion of recent promising preclinical and clinical results. · Focused ultrasound is able to deliver drugs in a very selective way.. · Focused ultrasound-mediated hyperthermia may be promising for treating bone infections.. · Focused ultrasound-mediated drug delivery may also be an elegant method for treating bone cancer and arthritis.. · Sassi R, Gazzotti S, Aparisi Gómez MP et al. Focused ultrasound-mediated drug delivery systems: a technological overview, possible musculoskeletal applications, and future directions. Rofo 2025; DOI 10.1055/a-2760-5392.

View details for DOI 10.1055/a-2760-5392

View details for PubMedID 41617152