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Distinct Phenotypes of Full-Thickness Rectal Prolapse in Women: A Comparison of Defecation-Only and Spontaneous Presentations.

Distinct Phenotypes of Full-Thickness Rectal Prolapse in Women: A Comparison of Defecation-Only and Spontaneous Presentations. Neurogastroenterology and motility Zhou, Z., Earley, M., Hoy, S. A., Sheth, V. R., Gurland, B., Neshatian, L. 2026; 38 (2): e70265

Abstract

While some patients report full thickness rectal prolapse (RP) exclusively during defecation, others may experience it spontaneously during walking, exercise, and/or all the time. We hypothesized that patients with RP only during defecation have more preserved physiological and anatomical characteristics and aimed to identify the phenotypes of patients with various RP expression.A retrospective analysis of a prospectively maintained registry of women with RP (2017-2023) included clinical characteristics, MRI defecography (MRD), and high-resolution anorectal manometry (HR-ARM).Of 297 patients, 147 (49%) experienced defecation-only RP, while 150 (51%) had spontaneous RP. The defecation-only RP group was younger (p?

View details for DOI 10.1111/nmo.70265

View details for PubMedID 41708524