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Beyond the Major Determinant: Patterns of Penicillin Skin Test Positivity.
Beyond the Major Determinant: Patterns of Penicillin Skin Test Positivity. The journal of allergy and clinical immunology. In practice Salciccioli, I., King, A. J., Accarino, J. J., Belmont, A., Fadugba, O. O., Gonzalez-Estrada, A., Khan, D. A., Liu, A., Otani, I. M., Phillips, E. J., Ramsey, A., Stone, C. A., Banerji, A., Blumenthal, K. G., USDAR Study Team 2026Abstract
CLINICAL IMPLICATIONS: Penicillin G and aminopenicillins skin testing identified nearly 90% of penicillin allergic patients, suggesting PREPEN is not essential for most evaluations and can be reserved for high-risk patients during shortages. Current skin testing strategies remain clinically valuable even without PPL, while direct oral challenge stays preferred for low-risk patients.
View details for DOI 10.1016/j.jaip.2026.07.021
View details for PubMedID 42498127