Multiparametric MRI—Representative case demonstrating the value of targeted prostate biopsy in a 60 year old man with a high blood level of PSA. He underwent three conventional prostate biopsies over 5 years that did not detect prostate cancer. During this time his PSA continued to rise. At Stanford, a multiparametric prostate MRI showed an area that was highly suspicious for cancer on T2-weighted imaging (A), contrast-enhanced imaging (B), and diffusion weighted imaging (C). Based on this result, a targeted prostate biopsy was scheduled.