Trial ID or NCT#

NCT02753101

Status

recruiting iconRECRUITING

Purpose

Chronic pain can result from injured or inflamed nerves, as occurs in people suffering from sciatica and CRPS. These nerve injuries or regions of nerve irritation are often the cause of pain in these conditions, but the current diagnostic tools are limited in pinpointing the area of origin. Several studies have implicated involvement of sigma-1 receptors in the generation and perpetuation of chronic pain conditions, others are investigating anti sigma-1 receptor drugs for the treatment of chronic pain. Using the sigma-1 receptor (S1R) detector and experimental radiotracer [18F]FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI) scanner, the researchers may potentially identify the source of pain generation in patients suffering from complex regional pain syndrome (CRPS) and chronic sciatica. The ultimate goal is to assist in the optimization of pain treatment regimens using an [18F]FTC-146 PET/MRI scan. The study is not designed to induce any physiological/pharmacological effect.

Official Title

Biodistribution and Pharmacokinetic Determination of the PET Radiopharmaceutical [18F]FTC-146 Using PET/MRI in Healthy (Asymptomatic) Volunteers and in Patients With CRPS and Sciatica

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes

Investigator(s)

Sanjiv Sam Gambhir, MD, PhD
Frederick T. Chin, Ph.D.
Ian Carroll, MD, MS
Ian Carroll, MD, MS
Headache specialist, Orofacial pain specialist, Pain management specialist
Associate Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain) at the Stanford University Medical Center
Catherine Curtin
Catherine Curtin
Hand and upper extremity surgeon
Professor of Surgery (Plastic & Reconstructive Surgery) and, by courtesy, of Orthopaedic Surgery at the Stanford University Medical Center
Sandip Biswal, MD
Sandip Biswal, MD
Radiologist
Associate Professor of Radiology (Musculoskeletal Imaging) at the Stanford University Medical Center
Vivianne Tawfik
Vivianne Tawfik
Anesthesiologist, Pain management specialist
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Adult Pain) at the Stanford University Medical Center

Contact us to find out if this trial is right for you.

CONTACT

Sandip Biswal, MD
(650) 725-8018