Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome

Trial ID or NCT#

NCT00149825

Status

not recruiting iconNOT RECRUITING

Purpose

This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.

Eligibility Criteria

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Diagnosis of major depressive disorder - HRSD(17) score of at least 14 - Presence and complaint of insomnia for at least 1 month - Fluent in English - Use of an effective form of contraception throughout the study
Exclusion Criteria:
  1. - Other psychiatric disorders (e.g., bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, eating disorder) - Psychotic symptoms - Serious, unstable, or terminal medical condition - Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder - Substance abuse - Not willing to end other psychiatric treatment - Previous electroconvulsive therapy or vagus nerve stimulation treatment during the last year - Sleep apnea, restless leg, or periodic limb movement disorder (to be ruled out after first sleep study) - Other sleep disorders - Currently pregnant or breastfeeding - History of seizure disorder - Disease or condition that produces altered metabolism or hemodynamic responses - Liver or kidney dysfunction - Current use of any over the counter medications or herbs for mood or sleep benefits (e.g., melatonin, valerian, kava, hop extract, St. John's Wort, SAMe)
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Investigator(s)

Rachel Manber, PhD
Rachel Manber, PhD
Sleep specialist, Pediatric sleep specialist, Psychologist
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)

View on ClinicalTrials.gov