Combining Antidepressant Medication and Psychotherapy for Insomnia to Improve Depression Outcome

Trial ID or NCT#



not recruiting iconNOT RECRUITING


This study will examine the effectiveness of a combination of antidepressant medication and sleep-focused psychotherapy to simultaneously treat sleep difficulties and depression.

Eligibility Criteria

Ages Eligible for Study: 18 Years to 75 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Diagnosis of major depressive disorder - HRSD(17) score of at least 14 - Presence and complaint of insomnia for at least 1 month - Fluent in English - Use of an effective form of contraception throughout the study
Exclusion Criteria:
  1. - Other psychiatric disorders (e.g., bipolar disorder, post traumatic stress disorder, obsessive compulsive disorder, eating disorder) - Psychotic symptoms - Serious, unstable, or terminal medical condition - Axis II diagnosis of antisocial, schizotypal, or severe borderline personality disorder - Substance abuse - Not willing to end other psychiatric treatment - Previous electroconvulsive therapy or vagus nerve stimulation treatment during the last year - Sleep apnea, restless leg, or periodic limb movement disorder (to be ruled out after first sleep study) - Other sleep disorders - Currently pregnant or breastfeeding - History of seizure disorder - Disease or condition that produces altered metabolism or hemodynamic responses - Liver or kidney dysfunction - Current use of any over the counter medications or herbs for mood or sleep benefits (e.g., melatonin, valerian, kava, hop extract, St. John's Wort, SAMe)


Rachel Manber, PhD
Rachel Manber, PhD
Sleep specialist, Pediatric sleep specialist, Psychologist
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology-Adult)