Comparative Renal Function of Young (18-45 Years) and Ageing (55 Years and Above) Kidney Donors
Trial ID or NCT#
Status
Purpose
It is our purpose in this study to compare the kidney structure and function of older patients to that of young patients before and after removal of a single kidney for transplant donation and to examine the remaining kidney's ability to adapt and maintain function over time. More specifically, we aim to examine the effect of uninephrectomy on adaptive hyperfiltration in the remaining kidney. A secondary aim is to investigate whether subjects in the aging population undergo compensation to the same extent as younger subjects. We will also examine the compensatory rise in GFR (glomerular filtration rate) that follows uninephrectomy in both groups, and, again, compare the results in the aged versus young subjects. This will help in delineating the extent to which the aging population can be a potential source of living kidney donors for kidney transplantation. It is also our purpose with this study to refine the tests to be used in the donor evaluation process so as to accurately identify ideal candidates for safe kidney donation.
Official Title
Preserving Renal Longevity in Living Kidney Donors
Eligibility Criteria
- 1. Patients who are over the age of 18. 2. Patients who are undergoing surgical uninephrectomy for the purpose of living donation for transplantation 3. Adults who had a single kidney removed for transplant donation 10-20 years ago. 4. All Patients enrolled in this study must be between the ages of 18 and 45 years or 55 years or older. 5. Patients undergoing surgery for kidney donation who exhibit mild hypertension controlled with one medication. Any age accepted
- 1. Patients under the age of 18. 2. Patients between the ages of 46 and 54 3. Patients who are allergic to Inulin, Iothalamate, or PAH. 4. Women who are pregnant. 5. Other "Vulnerable Subjects"
Investigator(s)
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Contact
Geraldine Derby, R.N.
650-723-5985
View on ClinicalTrials.gov