Children and Adolescents With Marfan Syndrome: 10,000 Healthy Steps and Beyond

Trial ID or NCT#

NCT03567460

Status

not recruiting iconNOT RECRUITING

Purpose

Marfan patients are at risk of sudden death due to weakening of the wall of the large blood vessel leading from the heart (aorta). The wall of the aorta weakens and dilates which can rupture, leading to death, and sometimes during intense exercise. There is some evidence in Marfan patients that a stiffer aorta increases risk for rupture. For some time, clinical care has focused on what type of exercise these patients should avoid due to risk for aortic dissection. Little clinical emphasis has been placed on encouraging patients to engage in routine and safe exercise such as walking. Informed by this evidence, the investigators propose to collaboratively investigate whether regular exercise improves aortic health in adolescent Marfan patients.

Official Title

Children and Adolescents With Marfan Syndrome: 10,000 Healthy Steps and Beyond

Eligibility Criteria

Ages Eligible for Study: 10 Years to 19 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. 1. 10-19 years of age,2. MFS by revised Ghent criteria,3. Cardiac clearance to exercise by the primary cardiologist.
Exclusion Criteria:
  1. 1. Ventricular dysfunction,2. Prior history of aortic surgery.

Investigator(s)

Seda Tierney

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Contact

Elif Seda M Selamet Tierney
650-736-8716