Duloxetine for the Treatment of Dysthymia

Trial ID or NCT#

NCT00185575

Status

not recruiting iconNOT RECRUITING

Purpose

The purpose of this study is to test the hypothesis that duloxetine (Cymbalta), in doses of 60 or 120 mg/day, is an effective and tolerable treatment for adult outpatients suffering from dysthymia. Dysthymia is chronic, mild depression characterized by feeling sad or low more days than not for more than 2 years.

Official Title

Duloxetine for the Treatment of Dysthymia

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. : - Sign an informed consent form - 18 years of age or older - Females not pregnant or breastfeeding or planning pregnancy and using an acceptable form of contraception - Meet DSM-IV criteria for dysthymia - A screening IDS-C score of 17 or greater - No history of serious or unstable medical disorder - Not taking any significant concurrent medications - Not currently receiving psychotherapy
Exclusion Criteria:
  1. - Suffering from DSM-IV defined - delirium, dementia, amnestic, or other cognitive disorders - mental disorders due to a general medical condition - factitious or somatoform disorders - mental retardation or developmental disabilities - substance or alcohol abuse within the last 3 months - depressive disorders with current suicidal risk - psychotic disorders including delusional disorder, somatic type - dissociative disorder - personality disorders sufficiently severe to interfere with study participation - History of DSM-IV defined bipolar I or II disorder - History of non-response of dysthymia to adequate antidepressant medication - History of major depression refractory to two adequate trials of antidepressants

Investigator(s)

Lorrin Koran
Elias Aboujaoude, MD, MA
Psychiatrist
Clinical Professor, Psychiatry and Behavioral Sciences

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Contact

Nona Gamel
6507255180