Extended Treatment for Smoking Cessation

Trial ID or NCT#

NCT01330043

Status

not recruiting iconNOT RECRUITING

Purpose

Adult smokers (21-65) and adolescent smokers (18 - 21) years of age residing in Alameda and Santa Clara counties will serve as the target population for this study. A total of 400 smokers meeting eligibility criteria will be randomized. Treatment will include both open label and extended treatment phases. Randomization. Participants will be randomized to extended therapy or control conditions at baseline (prior to open label treatment) and the analysis will be intention-to-treat (ITT) to avoid the threat of selection bias. Primary hypothesis. Smokers randomized to receive CBT during extended treatment will have a higher prolonged abstinence rate (PA) at 52 week and 104 week follow-up than participants in the Supportive therapy Control treatment.

Official Title

Extended Treatment for Smoking Cessation

Eligibility Criteria

Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. - Age at least 18 years at the beginning of the study Smoking at least 10 cigarettes a day (1/2 pack)
Exclusion Criteria:
  1. 1. Currently pregnant 2. Currently breastfeeding 3. Currently diagnosed with a seizure disorder, major depression, liver disease, kidney disease, congestive heart failure or diabetes mellitus 4. History of a seizure, seizure disorder, significant head trauma or central nervous system tumor 5. Family history of seizures 6. Currently using intravenous drugs 7. Currently using any drugs (marijuana, alcohol, cocaine, opiates, stimulants, etc.) on a daily basis 8. Currently using any over-the-counter stimulants and anorectics (diet pills) 9. Currently on bupropion (Wellbutrin, Wellbutrin SR) or other antidepressants, monoamine oxidase inhibitors, antipsychotics, benzodiazepines, theophylline, systemic steroids or levodopa 10. Currently on NRT or bupropion (Zyban) 11. Current or past diagnosis of anorexia nervosa or bulimia nervosa 12. Previous allergic response to bupropion or NRT

Investigator(s)

Joel Killen

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Contact

Erin Crew, M.P.H.
(408) 415-7301