Trial ID or NCT#

NCT02421887

Status

RECRUITING

Purpose

The objective of the Males, Antioxidants, and Infertility (MOXI) Trial is to examine whether treatment of infertile males with an antioxidant formulation improves male fertility. The central hypothesis is that treatment of infertile males with antioxidants will improve sperm structure and function, resulting in higher fertilization rates and improved embryo development, leading to higher pregnancy and live birth rates. Findings from this research will be significant in that they will likely lead to an effective, non-hormonal treatment modality for male infertility. An effective treatment for men would also reduce the treatment burden on the female partner, lower costs, and provide effective alternatives to couples with religious or ethical contraindications to ART (Assisted Reproductive Technology). If antioxidants do not improve pregnancy rates, but do improve sperm motility and DNA integrity, they could allow for couples with male factor infertility to use less intensive therapies such as intrauterine insemination. Male fertility specialists currently prescribe antioxidants based on the limited data supporting their use. A negative finding, lack of any benefit, would also alter current treatment of infertile males.

Official Title

Males, Antioxidants, and Infertility (MOXI) Trial

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: No

Investigator(s)

Valerie Baker, M.D.
Obstetrician/gynecologist, Fertility specialist
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility) at the Stanford University Medical Center
Michael Eisenberg
Urologist, Male fertility specialist, Male sexual function specialist
Assistant Professor of Urology and, by courtesy, of Obstetrics and Gynecology at the Stanford University Medical Center

Contact us to find out if this trial is right for you.

CONTACT

Oshra Sedan, PhD
(408) 688-9892