Magnesium for Peroral Endoscopic Myotomy

Trial ID or NCT#

NCT04638881

Status

not recruiting iconNOT RECRUITING

Purpose

Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will decrease postoperative esophgeal pain as measured by the esophageal symptoms questionnaire, while decreasing perioperative opioid requirements.

Official Title

A Prospective, Randomized, Double-blind, Placebo-controlled Trial of the Effects of Magnesium Sulfate on Postoperative Esophageal Spasm-associated Pain Following Peroral Endoscopic Myotomy

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Planned peroral endoscopic myotomy procedure
Exclusion Criteria:
  1. * cannot give consent* patients who are clinically unstable and/or require urgent/emergent intervention* previous esophageal myotomy* preexisting hypermagnesemia* end-stage renal disease* neuromuscular disease, including but not limited to Guillain-Barre syndrome, myasthenia gravis, congenital myopathy, and muscular dystrophy* preexisting heart failure* severe ventricular systolic dysfunction (left or right ventricle)
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Investigator(s)

Richard K. Kim
Joo Ha Hwang, MD, PhD
Joo Ha Hwang, MD, PhD
Gastroenterologist, Therapeutic endoscopy specialist, Large colon polyp specialist, Gastrointestinal surgeon, Endoscopic ultrasound specialist, Biliary specialist
Professor of Medicine (Gastroenterology and Hepatology) and, by courtesy, of Surgery

Contact us to find out if this trial is right for you.

Contact

Richard K Kim, MD
347-586-9661

View on ClinicalTrials.gov