Magnesium for Peroral Endoscopic Myotomy
Trial ID or NCT#
Postoperative pain after peroral endoscopic myotomy occurs due to involuntary esophageal smooth muscle spasms. Magnesium has antispasmodic properties as a smooth muscle relaxant. This study hypothesizes that among patients having peroral endoscopic myotomy, magnesium will decrease postoperative esophgeal pain as measured by the esophageal symptoms questionnaire, while decreasing perioperative opioid requirements.
A Prospective, Randomized, Double-blind, Placebo-controlled Trial of the Effects of Magnesium Sulfate on Postoperative Esophageal Spasm-associated Pain Following Peroral Endoscopic Myotomy
- - Planned peroral endoscopic myotomy procedure
- - cannot give consent - patients who are clinically unstable and/or require urgent/emergent intervention - previous esophageal myotomy - preexisting hypermagnesemia - end-stage renal disease - neuromuscular disease, including but not limited to Guillain-Barre syndrome, myasthenia gravis, congenital myopathy, and muscular dystrophy - preexisting heart failure - severe ventricular systolic dysfunction (left or right ventricle)
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Richard K Kim, MD