Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia

Trial ID or NCT#

NCT01516398

Status

not recruiting iconNOT RECRUITING

Purpose

A lung condition called bronchopulmonary dysplasia (BPD) is a major cause of poor outcomes and death for premature infants. Infants with BPD are also at high risk for pulmonary hypertension (PH)-an important contributor to their condition. Previous research has suggested that a protein in the blood, endothelin-1 (ET-1), is associated with pulmonary disease. This study aims to investigate the incidence of PH and levels of ET-1 among premature babies with BPD. It will also potentially allow us to focus further research efforts and treatment towards these infants, some of our sickest patients at LPCH.

Official Title

Endothelin-1 (ET-1) Levels as Predictors of Pulmonary Hypertension Risk in Premature Infants With Bronchopulmonary Dysplasia (BPD)

Eligibility Criteria

Ages Eligible for Study: Younger than 30 Weeks
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. - Premature Infants (<30 weeks EGA)
Exclusion Criteria:
  1. - Major congenital malformations (cardiac, respiratory, gastrointestinal) - congenital infection, and/or - known genetic syndromes (i.e. trisomy 21)

Investigator(s)

Christine Johnson

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Contact

Christine Johnson, MD
650 723-5711