Pharmacokinetics of Oral Calcium Carbonate in Parturients

Trial ID or NCT#

NCT06650930

Status

not recruiting iconNOT RECRUITING

Purpose

This study investigates the time course of change in calcium in the blood after a pregnant subject takes an oral dose of calcium carbonate (commonly marketed as "Tums"). This information is important for trials investigating whether calcium can reduce postpartum hemorrhage, bleeding after delivery.

Official Title

Pharmacokinetics of Oral Calcium Carbonate in Parturients

Eligibility Criteria

Ages Eligible for Study: 18 Years to 45 Years
Sexes Eligible for Study: FEMALE
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Pregnant female subjects at the study institution, admitted for labor (spontaneous, augmented, or induced)
Exclusion Criteria:
  1. 1. severe range blood pressure (BP \>160/\>110) within the 48 hours prior to delivery2. patient age \<18 years or \>45 years3. renal dysfunction with a documented serum Cr \> 1.0 mg/dL4. known history of congenital or acquired cardiac disease or history of arrhythmia5. patient taking digoxin6. patient currently taking a calcium channel blocker7. Weight \<55kg or \>100kg, or8. receiving magnesium infusion within 24 hours prior to or during cesarean delivery9. Prior or planned administration of calcium by the obstetric or anesthesiology teams for clinical indications within 24 hours of study enrollment10. Patient took a calcium supplement in the past 48 hours11. Patient status is NPO (nothing by mouth) as ordered by the clinical team
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Investigator(s)

Jessica Rose Ansari
Assistant Professor of Anesthesiology, Perioperative and Pain Medicine (Obstetrics)

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Contact

Jessica Ansari, MD, MS
650-723-4000

View on ClinicalTrials.gov