Safety and Tolerability Study of SNS-314 for Advanced Solid Tumors
Trial ID or NCT#
This is a study to assess the safety and tolerability of SNS-314 in advanced solid tumors in humans.
Phase 1 Open-Label Multicenter, Dose-Escalating, Clinical Study of the Safety, Tolerability, and Pharmacokinetic and Pharmacodynamic Profiles of SNS-314, a Novel Aurora Kinase Inhibitor, Administered to Patients With Advanced Solid Tumors
- - Advanced solid tumor and that is measurable by a scan
- - Uncontrolled or untreated central nervous system metastases - Cerebrovascular accident/transient ischemic attack up to 6 months before Cycle 1 Day 1 - Any of the following cardiac conditions: - History of myocardial infarction, acute coronary syndromes up to 12 weeks before Cycle 1 Day 1 - Class III or IV heart failure up to 6 months before Cycle 1 Day 1 - Baseline heart rate corrected QT interval (QTc)> 450 msec - History of ventricular arrhythmias up to 6 months before Cycle 1 Day 1 - Use of medications that prolong the QTc interval and are associated with Torsades de Pointe (TdP) - Previous cancer treatment up to 21 days before first dose - Any investigational therapy up to 28 days before Cycle 1 Day 1 - Known allergy to cyclodextrins Please note: There are additional inclusion/exclusion criteria for this study. Please contact the study center for additional information and to determine if all study criteria are met.
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