68Ga-PSMA PET/CT in Detecting Prostate Cancer Recurrence in Patients With Elevated PSA After Initial Treatment

Trial ID or NCT#



not recruiting iconNOT RECRUITING


The purpose of this research study is to see if recurrent prostate cancer can be identified using a special procedure called a positron emission tomography (PET) scan. PET/CT is used to describe information regarding the function, as well as location and size of a tumor.

Official Title

68-Ga PSMA 11 PET/CT for Detection of Recurrent Prostate Cancer After Initial Therapy in Patients With Elevated PSA

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Histopathological proven prostate adenocarcinoma - Rising prostate-specific antigen (PSA) after definitive therapy with prostatectomy or radiation therapy (external beam or brachytherapy) - Post radical prostatectomy (RP) - American Urology Association (AUA) recommendation - PSA greater than 0.2 ng/mL measured 6 to 13 weeks after RP - Confirmatory persistent PSA greater than 0.2 ng/mL (total of two PSA measurements greater than 0.2 ng/mL) - Post-radiation therapy -American Society for Radiation Oncology (ASTRO)-Phoenix consensus definition - A rise of PSA measurement of 2 or more ng/mL over the nadir - Karnofsky performance status of ≥ 50 (or Eastern Cooperative Oncology Group [ECOG] / World Health Organization [WHO] equivalent) - Able to provide written consent
Exclusion Criteria:
  1. - Investigational therapy for prostate cancer. - Unable to lie flat, still or tolerate a positron emission tomograpy (PET) scan. - Prior history of any other malignancy within the last 2 years, other than skin basal cell or cutaneous superficial squamous cell carcinoma that has not metastasized and superficial bladder cancer.


Andrei Iagaru
Andrei Iagaru
Professor of Radiology (Nuclear Medicine)

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David Marcellus