Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis
Trial ID or NCT#
Status
Purpose
Chorioamnionitis is an infection of the placenta and amniotic membranes (bag of waters) surrounding the baby inside of a pregnant woman prior to delivery. This infection is somewhat common and is routinely treated with antibiotics given to the mother both before and after the baby is born. Currently it is not known what is the best choice of antibiotics to treat this type of infection, but commonly used treatments include Unasyn (ampicillin/sulbactam) or ampicillin/gentamicin. We plan to compare these two different antibiotic regimens to see if one is better than the other at treating and preventing bad outcomes from chorioamnionitis in women and babies.
Official Title
Comparison of Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Intrapartum Chorioamnionitis: a Randomized Controlled Trial
Eligibility Criteria
- 1. Pregnant women in labor or undergoing induction of labor2. Greater than or equal to 18 years of age3. Diagnosed with chorioamnionitis as defined by maternal temperature \> or = 38.0 degrees Centigrade plus at least one of the following: maternal tachycardia (heart rate \>110), fetal tachycardia (fetal heart rate baseline \>160), purulent amniotic fluid, uterine tenderness.
- 1. Allergy or adverse reaction to penicillin or ampicillin, gentamicin, or sulbactam2. Having received antibiotics for the treatment of preterm premature rupture of membranes or other condition within the last 7 days3. Acute or chronic renal disease or insufficiency (creatinine \>1.0)4. Hearing loss5. Major fetal congenital anomalies or intrauterine fetal demise6. Neutropenia7. HIV8. Myasthenia gravis or other neuromuscular disorder
Investigator(s)
Contact us to find out if this trial is right for you.
Contact
Mara Greenberg
4158672051
View on ClinicalTrials.gov