Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
Trial ID or NCT#
Status
Purpose
The purpose of this study is to determine if patients with recurrent pregnancy loss or unexplained infertility have an altered uterine gene expression or uterine microbiome (micro-organism composition) during the window of embryo implantation. Furthermore we would like to assess for women with an abnormal uterine gene expression whether vaginal progesterone medication improves or alters gene expression and for women with an abnormal microbiome whether antibiotic treatment followed by probiotic treatment normalizes the microbiome.
Official Title
Assessing the Endometrial Environment in Recurrent Pregnancy Loss and Unexplained Infertility
Eligibility Criteria
- 1. Recurrent Pregnancy Loss Inclusion: - Age 18-45 - 3 or more SABs including biochemical pregnancies OR 2 or more SABs if one is documented to be euploid Exclusion: - irregular menstrual cycles - Submucosal fibroid >3cm - Stage 3-4 endometriosis - BMI >40 - IUD within the last 3 months 2. Unexplained infertility Patients Inclusion: - TTC x >= 1 year - At least one SA with TMS >10 mil within last 2 years - At least one patent fallopian tube documented by HSG or SHG - Cycle length 25-35 days Exclusion: - Irregular menstrual cycles - Submucosal fibroid >3cm - Stage 3-4 endometriosis - BMI >40 - IUD within the last 3 months - Less then 2 SABs including biochemical pregnancies 3. Healthy control patients Inclusion: - Patients who present for fertility preservation, sex selection, same sex couples needing fertility care, preconception counseling - 1 or more live births Exclusion: - Irregular menstrual cycles - Submucosal fibroid >3cm - Stage 3-4 endometriosis - BMI >40 - IUD within the last 3 months - Less then 2 SABs including biochemical pregnancies - No history of RPL or infertility
Investigator(s)
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Contact
Sara J Churchill, MD
617-513-4997
View on ClinicalTrials.gov