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A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
Trial ID or NCT#
Status
RECRUITING
Purpose
This is a Phase 1/1b, open-label, first in human study of CPI-818, an oral interleukin-2-inducible tyrosine kinase (ITK) inhibitor for the treatment of relapsed/refractory (R/R) T-cell lymphoma.. This trial will study the safety, tolerability, and anti-tumor activity of CPI-818 as a single drug.
Official Title
A Phase 1/1b Dose-Escalation Trial Evaluating CPI-818, an Oral Interleukin-2-Inducible T-Cell Kinase Inhibitor, in Subjects With Relapsed/Refractory T-Cell Lymphoma
Eligibility Criteria
- - Adult subjects age ≥18 years - Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1 - Histologically confirmed evidence of T-cell lymphoma - Measurable disease. - Adequate organ function. - At least 2 standard therapies for advanced or recurrent disease or had a disease for which there is no more than one established therapy.
- - Treatment with systemic immunosuppressive medication. - History of allogeneic hematopoietic stem cell transplantation. - History of primary immunodeficiency, solid organ transplantation. - History of opportunistic infection within 180 days of starting study drug. - Females who are pregnant, lactating, or intend to become pregnant - History of invasive prior malignancy that required systemic therapy within last 3 years. - Concomitant use of strong inhibitors or inducers of CYP3A.
Investigator(s)
Contact us to find out if this trial is right for you.
CONTACT
Elle Kim
(650) 387-4436
View on ClinicalTrials.gov
About this Clinical Trial
A Dose Escalation Study Evaluating CPI-818 in Relapsed/Refractory T-Cell Lymphoma
Your Message Will Go To
Elle Kim650-387-4436