A Study Measuring the Effectiveness, Safety, and Tolerability of BMS-986278 in Participants With Lung Fibrosis

Trial ID or NCT#

NCT04308681

Status

not recruiting iconNOT RECRUITING

Purpose

The purpose of this study is to provide an initial evaluation of the effectiveness of BMS-986278 in participants with lung fibrosis, to demonstrate the safety of BMS-986278, and provide information on the drug levels of BMS-986278 in these participants.

Official Title

A Multicenter, Randomized, Double-blind, Placebo-controlled, Phase 2 Study of the Efficacy and the Safety and Tolerability of BMS-986278 in Participants With Pulmonary Fibrosis

Eligibility Criteria

Ages Eligible for Study: Older than 21 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. For the idiopathic pulmonary fibrosis (IPF) Cohort
    1. * Diagnosis of IPF within 7 years of screening* Female and males ≥ 40 years of age
  2. For the progressive fibrotic interstitial lung disease (PF-ILD) Cohort
    1. * Evidence of progressive ILD within the 24 months before screening* Female and male ≥ 21 years of age.
Exclusion Criteria:
  1. * Women of childbearing potential (WOCBP)* Active Smokers* Current malignancy or previous malignancy up to 5 years prior to screening* History of allergy to BMS-986278 or related compounds
    1. Other protocol-defined inclusion/exclusion criteria apply
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Investigator(s)

Rishi Raj
Rishi Raj
Pulmonologist
Clinical Professor, Medicine - Pulmonary, Allergy & Critical Care Medicine

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Contact

Rishi Raj, Site 0043
650-736-8083

View on ClinicalTrials.gov