A Phase 2 Study of CRG-022 in Patients With Relapsed/Refractory Large B-cell Lymphoma
Trial ID or NCT#
Status
RECRUITING
Purpose
This is a prospective, open-label, multi-center clinical study designed to evaluate the safety, tolerability, efficacy, pharmacokinetics, pharmacodynamics, and immunogenicity of CRG-022, a CD22-directed autologous Chimeric Antigen Receptor (CAR) T-cell therapy for the treatment of relapsed or refractory large B-cell lymphoma (LBCL).
Official Title
An Open-label, Multicenter Phase 2 Study Evaluating the Efficacy and Safety of CRG-022, a CD22-directed Autologous Chimeric Antigen Receptor (CAR) T-cell Therapy in Patients With Relapsed/Refractory Large B-Cell Lymphoma After CD19-directed CAR T-cell Therapy
Eligibility Criteria
- - Aged ≥18 years - Relapsed or refractory large B-cell lymphoma. - For enrollment in cohort 1, patients must have previously received a CD19-directed CAR T-cell therapy - Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 - Adequate hematological, renal, and liver function Key
- - Clinically significant concurrent medical illness - Active infection requiring systemic antibiotics - Prior allogeneic stem cell transplant or allogeneic cell therapy Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Investigator(s)
Contact us to find out if this trial is right for you.
Contact
Kelly Chyan
650-625-8130
View on ClinicalTrials.gov
