Clinical and Biological Characteristics of Psychotic Depression
Trial ID or NCT#
The primary objective of this study is to investigate the relationships among findings in structural and functional neuroimaging, cognitive testing and HPA (hypothalamic-pituitary-adrenal) axis dysregulation in psychotic depression.
Hypothalamic-Pituitary-Adrenal (HPA)/ Dopamine Axis in Psychotic Depression
- Inclusion criteria for PMD (individuals with Psychotic Major Depression) and NPMDs (individuals with Non-Psychotic Major Depression) are as follows:
- 1. DSM IV diagnosis of Major Depressive Disorder with or without psychotic features, Bipolar II Disorder with or without psychotic features in a major depressive episode.
- 2. 21-item HAM-D score greater than or equal to 21.
- 3. Thase Core Endogenomorphic Scale score greater than or equal to 6 on the items included in the 21-item HDRS.
- 4. Between 21 - 85 years of age.
- 5. If currently taking antipsychotic, antidepressant, anticonvulsant, and/or mood-stabilizing medications, must be stable on the medication for at least one-week prior to entering the study.
- 6. Pre-existing (current) primary treating psychiatrist for subjects with psychotic features.
- 7. Any secondary diagnoses from the anxiety disorder spectrum is acceptable. Primary pre-existing chronic Obsessive-Compulsive Disorder(OCD) will be an exclusion criteria.
- Inclusion criteria for healthy controls are as follows:
- 1. Between 21 - 85 years of age. 2. Taking no medications 3. Have a HAM-D score of less than or equal to 5.
- Exclusion criteria for PMDs and NPMDs are as follows:
- 1. ECT in the 4 months prior to the study.
- 2. Abuse of drugs or alcohol in the 6 months prior to study.
- 3. Unstable or untreated hypertension, or cardiovascular disease.
- 4. If participating in the blood draw portion of the protocol, endocrine disorders are exclusionary.
- 5. Use of additional prescription medications, street drugs, or alcohol during the week before the study.
- 6. Any Axis II diagnosis or traits which would make participation in the study difficult.
- 7. Current pregnancy or lactation.
- Exclusion criteria for healthy controls:
- 1. Personal history of Axis I or Axis II disorders.
- 2. Active unstable medical problems.
- 3. Abuse of drugs or alcohol in the 6 months prior to study.
- 4. Use of additional prescription medications, street drugs, or alcohol during the week before the study.
- 5. Currently pregnant or lactating.
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