Computational Drug Repurposing for All EBS Cases

Trial ID or NCT#

NCT03269474

Status

recruiting iconRECRUITING

Purpose

The study will compare gene expression differences between blistered and non-blistered skin from individuals with all subtypes of EB, as well as normal skin from non-EB subjects. State of the art computational analysis will be performed to help identify new drugs that might help all EB wound healing and reduce pain. Researchers will focus on drugs that have already been approved for treatment of other dermatologic or non-dermatologic diseases, and therefore be repurposed for treatment of EB. Drug development is a very expensive process taking decades for execution. Drug repurposing on the other hand, significantly reduces the cost and shortens the amount of time that is needed to bring effective treatments to clinical use. To date, there is no specific treatment targeting the physiology and immunologic response in EB patients during wound healing. Market availability of repurposed medications will provide all EB patients rapid access to treatments, thus improving their quality of life.

Official Title

Computational Drug Repurposing for All Epidermolysis Bullosa Simplex (EBS) Cases

Eligibility Criteria

Ages Eligible for Study: Older than 0 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. * Subjects of all ages* Diagnosis of all subtypes of EB subjects* Healthy, non-EB subjects* Ability to complete study visit to collect tissue and blood specimen
Exclusion Criteria:
  1. * Pregnancy, breast feeding* Prior history of liver disease* Serious known concurrent medical illness or infection, which could potentially present a safety risk and/or prevent tissue collection from subjects

Investigator(s)

Joyce Teng, MD, PhD
Joyce Teng, MD, PhD
Dermatologist, Pediatric dermatologist
Professor of Dermatology and, by courtesy, of Pediatrics
Kavita Sarin, MD, PhD
Kavita Sarin, MD, PhD
Dermatologist, General dermatologist, Cutaneous oncology specialist
Associate Professor of Dermatology
Lynne Nicole Martin
Interventional radiologist, Radiologist
Clinical Instructor, Radiology

Contact us to find out if this trial is right for you.

Contact

Karima Belhocine
650-723-0636