Development of 3DMPUS as a Decision Support Tool for Patients With Liver Tumors Undergoing Therapy

Trial ID or NCT#



recruiting iconRECRUITING


This clinical trial studies how well 3-dimensional multi-parametric ultrasound (3D MPUS) imaging works as a decision-support tool for patients with liver tumors undergoing therapy. Continuous and dynamic imaging of patients undergoing therapy is required to monitor early-phase treatment response. 3D-MPUS is an inexpensive and safe method, which may provide complementary quantitative functional (perfusion) and tissue characterization information to anatomical radiological assessment or blood biomarkers.

Official Title

Development of 3DMPUS as a Decision Support Tool for Patients With Liver Tumors Undergoing Therapy

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. 1. The participant is about to undergo a new course of therapy for primary or metastatic liver cancer. 2. The participant is age > 18 years. 3. Participant has at least one target lesion (≥1cm and <14cm) 4. The participant is willing to comply with protocol requirements. 5. The participant has the ability to understand and the willingness to sign a written informed consent document.
Exclusion Criteria:
  1. 1. Participant has documented anaphylactic or other severe reactions to any ultrasound or CT contrast media. 2. Participant has documented severe Hypersensitivity to macrogol/ polyethylene glycol (PEG). 3. Participant has documented the presence of a cardiac shunt or pulmonary hypertension (pulmonary artery pressure >90 mmHg). 4. Participant has documented renal insufficiency with a creatinine level of >1.5mg/dl. 5. Participant has documented uncontrolled systemic hypertension. 6. Participant has documented concomitant diseases like acute endocarditis, prosthetic valve, hyperactive coagulation states and/ or recent thromboembolism, and sepsis 7. Participant is pregnant (positive urine or serum beta-hCG) or lactating.


Aya Kamaya, MD
Aya Kamaya, MD
Professor of Radiology (Body Imaging)

Contact us to find out if this trial is right for you.


David Marcellus, BS