Effect of Different Skin Creams on TEWL

Trial ID or NCT#

NCT03663673

Status

not recruiting iconNOT RECRUITING

Purpose

Prospective, single center, clinical pilot study to test the hypothesis that lipid rich EpiCeram® is superior in improving skin barrier function compared to Aveeno Daily Moisturising Sheer Hydration Lotion®.

Official Title

Comparison of Two Different Skin Creams and Their Effect on Transepidermal Water Loss (TEWL) in Pediatric and Adult Patients With Atopic Dermatitis: A Pilot Study

Eligibility Criteria

Ages Eligible for Study: 1 Day to 40 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. 1. Parent guardian must be able to understand and provide informed consent per Institutional Review Board (IRB) guidelines and regulations. 2. Male or female participants, between the ages of 0 to 40 years will be included 3. Diagnosis of moderate to severe active AD (Scoring Atopic Dermatitis (SCORAD) score > 26) without a history or current manifestations of eczema herpeticum (EH) 4. AD affecting at least 3 different skin areas (contralateral arms and one lower extremity)
Exclusion Criteria:
  1. 1. Inability or unwillingness of a parent guardian to give written informed consent, or to comply with study protocol. 2. Participants with skin disease other than AD that might compromise the stratum corneum barriers (e.g., bullous diseases, psoriasis, cutaneous T-cell lymphoma (also called Mycosis Fungoides or Sezary syndrome], dermatitis herpetiformis, Hailey-Hailey, or Darier's disease). 3. Known or suspected immunosuppression 4. Severe concomitant illness(es) 5. History of serious life-threatening reaction to latex, tape, or adhesives 6. Has received total body phototherapy (e.g., ultraviolet light B [UVB], psoralen ultraviolet light A [PUVA], tanning beds [>1 visit per week]) within 30 days of the Enrollment Visit 7. Use of topical corticosteroids, topical immunomodulatory agents (such as calcineural inhibitors and crisaborole), or topical antibiotics on the upper or lower extremities within 7 days of the Enrollment Visit 8. Has taken a bleach bath within 7 days of the Enrollment Visit 9. Use of systemic antibiotics, antiparasitics, antivirals, or antifungals within 7 days of the Enrollment Visit.
View All Criteria
Show Less

Investigator(s)

Sayantani Sindher
Allergist, Immunologist
Clinical Associate Professor, Medicine Clinical Associate Professor, Pediatrics - Allergy and Clinical Immunology

View on ClinicalTrials.gov