Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Trial ID or NCT#
NCT05940324
Status
RECRUITING
Purpose
The purpose of this study is to understand how ketamine works in the brain to bring about a reduction in OCD symptoms.
Official Title
Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
Eligibility Criteria
Ages Eligible for Study: 18 Years to 65 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
- - Ages 18-65 - Meet the criteria for OCD diagnosis - Failed at least 1 prior trial of standard first-line OCD treatment - Agree to the following lifestyle modifications: comply with requirements for fasting prior to the Experimental Session, not enroll in any other interventional clinical trials during the duration of the study, and commit to medication study procedures. - Able to provide informed consent
Exclusion Criteria:
- - prior naltrexone or ketamine use/exposure - Any current or past medical/psychiatric condition that makes participation unsafe in the opinion of the investigator or study physician - Pregnant or nursing, or able to become pregnant and are not practicing an effective means of birth control - the presence of metal in the body that is contraindicated for MRI scans Eligibility Criteria for Healthy Volunteers: Inclusion Criteria: - Ages 18-65 - Able to provide informed consent Exclusion Criteria: - current or past use of psychotropic medication - pregnant or nursing females - the presence of metal in the body that is contraindicated for MRI scans
Investigator(s)
Carolyn Rodriguez
Psychiatrist
Professor of Psychiatry and Behavioral Sciences (Public Mental Health and Population Sciences)
Contact us to find out if this trial is right for you.
Contact
Pavithra Mukunda, MS
6504972578
View on ClinicalTrials.gov
