Human Mesenchymal Stromal Cells For Acute Respiratory Distress Syndrome (START)
Trial ID or NCT#
Status
Purpose
This was a Phase 2a, randomized, double-blind, placebo-controlled, multi-center trial to assess the safety and efficacy of a single dose of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (hMSCs) infusion in patients with Acute Respiratory Distress Syndrome (ARDS).
Official Title
Prospective, Randomized, Multi-center Phase 2 Clinical Trial of Allogeneic Bone Marrow-derived Human Mesenchymal Stromal Cells (hMSCs) for the Treatment of Acute Respiratory Distress Syndrome (ARDS)
Eligibility Criteria
- Patients will be eligible for inclusion if they meet all of the below criteria. Criteria 1-3 must all be present within a 24-hour time period and at the time of enrollment:
- Acute onset (defined below) of:
- 1. A need for positive pressure ventilation by an endotracheal or tracheal tube with a PaO2/FiO2 ratio \< 200 with at least 8 cm H2O positive end-expiratory airway pressure (PEEP)2. Bilateral infiltrates consistent with pulmonary edema on frontal chest radiograph3. No clinical evidence of left atrial hypertension for bilateral pulmonary infiltrates.
- 1. Age less than 18 years2. Greater than 96 hours since first meeting ARDS criteria per the Berlin definition of ARDS3. Pregnant or breast-feeding4. Prisoner5. Presence of any active malignancy (other than non-melanoma skin cancer) that required treatment within the last 2 years6. Any other irreversible disease or condition for which 6-month mortality is estimated to be greater than 50%7. Moderate to severe liver failure (Childs-Pugh Score \> 12)8. Severe chronic respiratory disease with a PaCO2 \> 50 mm Hg or the use of home oxygen9. Patient, surrogate, or physician not committed to full support (exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest)10. Major trauma in the prior 5 days11. Lung transplant patient12. No consent/inability to obtain consent13. Moribund patient not expected to survive 24 hours14. World Health Organization (WHO) Class III or IV pulmonary hypertension15. Documented deep venous thrombosis or pulmonary embolism within past 3 months16. No arterial line/no intent to place an arterial line17. No intent/unwillingness to follow lung protective ventilation strategy or fluid management protocol18. Currently receiving extracorporeal life support (ECLS) or high-frequency oscillatory ventilation (HFOV)
Investigator(s)
Contact us to find out if this trial is right for you.
Contact
Rosemary Vojnik
650-723-7409
View on ClinicalTrials.gov