Is Dexmedetomidine Associated With a Lower Incidence of Postoperative Delirium When Compared to Propofol or Midazolam in Cardiac Surgery Patients
Trial ID or NCT#
Status
Purpose
The purpose of this chart review study is to determine whether the use of dexmedetomidine, a selective α2-adrenergic receptor agonist with sedative, analgesic, and antinociceptive properties, would be associated with a lower incidence of delirium when compared to propofol and midazolam. We hypothesize that sedation with dexmedetomidine following cardiac surgery with CPB will be associated with a lower incidence of postoperative delirium.
Official Title
ICU Delirium: Can Dexmedetomidine Reduce Its Incidence?
Eligibility Criteria
- 1. Diagnosis of a coronary artery disease, cardiac valve disease, or vascular problems requiring elective surgical intervention2. Age older than 18 years of age, less than 90 years of age3. Fluency in English, and willingness to participate in the study4. No history of recent (\< 3 months) of alcohol or drug abuse5. No pre-operative evidence of heart block6. No history of dementia, schizophrenia, or post-traumatic stress disorder
- 1. A preexisting diagnoses of dementia, schizophrenia, active or recent alcohol or drug abuse/dependence; post-traumatic stress disorder; acute intoxication (i.e., positive urine drug and/or alcohol test at the time of initial evaluation or upon hospitalization for surgery)2. Age younger than 18, or older than 89 years of age3. Inability to understand enough English to complete required diagnostic testing4. Unwillingness to participate in the study5. Inability of subject or surrogate to consent.6. Pregnancy
Investigator(s)
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