LIPS-A: Lung Injury Prevention Study With Aspirin
Trial ID or NCT#
NCT01504867
Status
RECRUITING
Purpose
The primary hypothesis was that early aspirin administration will decrease the rate of developing acute lung injury during the first 7 days after presentation to the hospital.
Official Title
LIPS-A: Lung Injury Prevention Study With Aspirin
Eligibility Criteria
Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
- - Adult patients (age > 18) admitted to the hospital through the emergency department (ED) - At high risk of developing acute lung injury (ALI) Lung Injury Prediction Score (LIPS) greater than or equal to 4
Exclusion Criteria:
- - Anti-platelet therapy on admission or within 7 days prior to admission - Presented to outside hospital ED > 12 hrs before arrival at site's facility - Inability to obtain consent within 12 hours of hospital presentation - Admitted for elective surgery - Acute lung injury prior to randomization - Receiving mechanical ventilation through a tracheostomy tube prior to current hospital admission (patient who is ventilator dependent) - Presence of bilateral pulmonary infiltrates on admission if he or she has a history of bilateral pulmonary infiltrates (as evidenced by previous x-rays) that can reasonably explain the current degree of pulmonary infiltrates present. - Presentation due to pure heart failure and no other known risk factors for ALI. - Allergy to aspirin or non steroidal anti inflammatory drugs (NSAIDs) - Bleeding disorder - Suspected active bleeding or judged to be at high risk for bleeding - Active peptic ulcer disease (within past 6 months) - Severe chronic liver disease - Inability to administer the study drug - Expected hospital stay < 48 hours - Admitted for comfort or hospice care - Patient, surrogate or physician not committed to full support. (Exception: a patient will not be excluded if he/she would receive all supportive care except for attempts at resuscitation from cardiac arrest) - Not anticipated to survive > 48 hours - Previously enrolled in this trial - Enrolled in a concomitant intervention trial - Pregnant or breastfeeding
Investigator(s)
Joseph Levitt, MD, MS
Pulmonary critical care specialist,
Pulmonologist,
Critical care specialist
Associate Professor of Medicine (Pulmonary and Critical Care Medicine)
Contact us to find out if this trial is right for you.
Contact
Rosemary Vojnik
650-723-7409
View on ClinicalTrials.gov
