Long-term Cognitive, Neuropsychiatric and Functional Outcomes in Adults Who Have Received Chimeric Antigen-Receptor T-Cell (CAR-T) Therapy for Aggressive Lymphoma at Stanford

Trial ID or NCT#

NCT05416554

Status

not recruiting iconNOT RECRUITING

Purpose

This study aims to assess the feasibility of performing neuropsychological testing to measure the cognitive performance of individuals following Axicabtagene ciloleucel CAR-T therapy at Stanford.

Official Title

Long-term Cognitive, Neuropsychiatric and Functional Outcomes in Adults Who Have Received Chimeric Antigen-Receptor T-Cell (CAR-T) Therapy for Aggressive Lymphoma at Stanford - A Pilot Study

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - >/= 18 years-old - Treated with Axicabtagene ciloleucel CAR-T therapy at Stanford Or - Treated with standard commercial Axicabtagene ciloleucel CAR-T therapy elsewhere and followed primarily by SHC Blood and Bone Marrow transplant providers - >/= 6 months from the date of CAR-T infusion - Fluent in English - Able to attend and participate in in-person testing (Arm I) - Able to participate in remote video testing with adequate workspace, computer and internet capabilities for a reliable telehealth video connection (Arm II)
Exclusion Criteria:
  1. - Concurrent enrollment in a CAR-T therapeutics research study - Unable to be present for the scheduled testing - Unable to participate in testing due to severe cognitive or physical limitation - Actively receiving chemotherapy - Progressive cancer
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Investigator(s)

Brian J Scott
Neurohospitalist
Clinical Professor, Neurology & Neurological Sciences Clinical Associate Professor (By courtesy), Neurosurgery
Matthew Frank
Blood and marrow transplant specialist, Hematologist-Oncologist
Assistant Professor of Medicine (Blood and Marrow Transplantation and Cellular Therapy)
Michelle Monje

Contact us to find out if this trial is right for you.

Contact

Brian J Scott, MD
bjscott@stanford.edu

View on ClinicalTrials.gov