Non-myeloablative Allogeneic Transplantation for the Treatment of Multiple Myeloma
Trial ID or NCT#
Status
Purpose
Mixed chimerism transplantation is an approach to allogeneic transplants that attempts to decrease regimen-related toxicity by using non-myeloablative preparatory regimens; establish mixed chimerism using low dose total body irradiation along with immunosuppression using cyclosporine and mycophenolate mofetil; suppress graft-vs-host and host-vs-graft reactions to allow a mixed chimeric state to be established, encourage tolerance and prevent graft-vs-host disease (GvHD) during the mixed chimerism period and use donor lymphocyte infusions to convert the patient to a full chimera while developing a graft-vs-tumor effect.
Official Title
Non-myeloablative Allogeneic Transplantation for the Treatment of Multiple Myeloma
Eligibility Criteria
Investigator(s)
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Contact
BMT Referrals
6507230822
View on ClinicalTrials.gov