Optimization of Time-of-Flight Mass Cytometry (CyTOF) Analysis for Evaluation of Immune Changes Following Surgery

Trial ID or NCT#

NCT01882569

Status

not recruiting iconNOT RECRUITING

Purpose

Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study is to use a single cell flow cytometry approach to characterize the cellular and molecular mechanisms involved in the inflammatory response to surgical trauma.

Official Title

Detection of Immune Changes as a Result of Surgical Trauma in Human Back Surgery Subjects: Optimization of CyTOF Analysis

Eligibility Criteria

Ages Eligible for Study: 18 Years to 90 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. 1. Ages 18 - 902. Men and women3. Undergo back surgery
Exclusion Criteria:
  1. 1. Any systemic disease that might compromise the immune system (e.g. lupus)2. Current diagnosis of cancer3. Any condition that, in the opinion of the investigator, might compromise the integrity of the study or safety of the participant.4. Unwilling to sign informed consent
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Investigator(s)

Martin S. Angst
Martin S. Angst
Anesthesiologist
Professor of Anesthesiology, Perioperative and Pain Medicine (MSD)

View on ClinicalTrials.gov