New to MyHealth?
Manage Your Care From Anywhere.
Access your health information from any device with MyHealth. You can message your clinic, view lab results, schedule an appointment, and pay your bill.
ALREADY HAVE AN ACCESS CODE?
DON'T HAVE AN ACCESS CODE?
NEED MORE DETAILS?
MyHealth for Mobile
Get the iPhone MyHealth app »
Get the Android MyHealth app »
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
Trial ID or NCT#
Status
Purpose
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
Official Title
A Phase 2, Multi-Center, Open-Label, Ascending Dose Study on the Efficacy, Safety and Tolerability of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure With Preserved Left Ventricular Function
Eligibility Criteria
- - Hypertrophic cardiomyopathy with symptoms of moderate-to-severe heart failure - Left ventricular hypertrophy with maximum LV wall thickness ≥ 15 mm - Left ventricular ejection fraction ≥ 50% - Able to perform exercise testing but unable to exceed 75% of the predicted age-adjusted maximum level Key
- - CYP2D6 Poor Metabolizer (PM) status - History of a known chronic liver disease - ALT, AST, alkaline phosphatase, or LDH > 1.5 x upper limit of normal - Total Bilirubin > 2.0 x upper limit of normal - Severe LV outflow obstruction - Asymptomatic patients or cardiomyopathy-related criteria as per protocol - QT interval related criteria as per protocol
Investigator(s)
Contact us to find out if this trial is right for you.
CONTACT
Austin Bland
(650) 725-6911
View on ClinicalTrials.gov
About this Clinical Trial
Your Message Will Go To
Austin Bland6507256911