Paramedic Treatment of Prolonged Seizures by Intramuscular Versus Intravenous Anticonvulsant Medications
Trial ID or NCT#
The goal of this non-inferiority trial is to determine which type of routine care is the best for paramedics to stop someone from seizing.
A Double-blind Randomized Clinical Trial of the Efficacy of IM Midazolam Versus IV Lorazepam in the Pre-hospital Treatment of Status Epilepticus by Paramedics
- - Paramedics or reliable witnesses verify 5 minutes of either continuous seizure activity or of repeated convulsive seizure activity where the patient does not regain consciousness (operationally defined as meaningful speech or obeying commands) between seizures. - Patient is still seizing at the time of paramedic treatment with study medications. - Estimated weight equal to or greater than 13 kg. - Subject to be transported to a RAMPART participating hospital.
- - Major trauma as the precipitant of the seizure - Hypoglycemia (as defined by local EMS protocol or a glucose < 60 mg/dL) - Known allergy to midazolam or lorazepam - Cardiac arrest or heart rate (HR) <40 beats per minute - Sensitivity to benzodiazepines - Medical alert tag marked with "RAMPART declined" - Prior treatment of this seizure with diazepam autoinjector as part of another study - Known pregnancy - Prisoners
Contact us to find out if this trial is right for you.