Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies
Trial ID or NCT#
NCT01163526,9,29,55,46552
Status
NOT RECRUITING
Purpose
A research study of liver perfusion (how blood flows to the liver over time). We hope to learn whether perfusion characteristics of liver masses may be predictive of response to treatment and whether liver perfusion characteristics can be used to follow response to treatment.
Official Title
Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies
Eligibility Criteria
Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
- 3.1.1 Patients with suspected or biopsy-proven liver masses including unresectable hepatocellular carcinoma (HCC), unresectable colon cancer metastases to the liver, and metastatic neuroendocrine tumors to the liver will be eligible for enrollment. 3.1.2 Patients who have undergone prior chemotherapy more than one year prior to the study are eligible for enrollment. 3.1.4 Patients must be 18 years or older. Patients must not be pregnant and, if of child-bearing age, must take precautions not to become pregnant. 3.1.5 No life expectancy restrictions. 3.1.6 ECOG and Karnofsky Performance Status will not be employed. 3.1.7 Patients with renal failure are ineligible for this study (Glomerular filtration rate (GFR) must be > 60) 3.1.8 Ability to understand and willingness to sign a written informed consent document.
Exclusion Criteria:
- 3.2.1 Patients who have undergone prior chemoembolization of hepatocellular carcinoma (HCC) are ineligible for enrollment. Patients who have undergone chemotherapy within one year prior to the study are also ineligible for enrollment. 3.2.2 No restrictions regarding use of other investigational agents. 3.2.3 Patients with severe contrast allergy are ineligible. 3.2.4 Patients who are pregnant or are trying to become pregnant are excluded from this study. 3.2.5 Patients who are cancer survivors or Human Immunodeficiency Virus (HIV)-positive will not be excluded.
Investigator(s)
Samuel So, MD
Surgical oncologist,
Liver surgeon,
General surgeon
Lui Hac Minh Professor in the School of Medicine
George A. Fisher Jr.
Medical oncologist,
Gastrointestinal specialist
Colleen Haas Chair in the School of Medicine
Contact us to find out if this trial is right for you.
Contact
Elizabeth Chitouras
650-498-0623
View on ClinicalTrials.gov
