Performance-Enhancing Effects of Platelet-Rich Plasma (PRP) Injections

Trial ID or NCT#



not recruiting iconNOT RECRUITING


Platelet-Rich Plasma (PRP) has been banned in competitive athletes because some people think it may enhance athletic performance. However, there is very little published research to support or undermine this point of view. The purposes of this study are: (1) To assess the effects of local platelet-rich plasma (PRP) therapy on systemic levels of growth factors with suspected or known performance-enhancing effects; and (2) To understand whether the effect of PRP therapy on these growth factors differs between intramuscular and intratendinous PRP injections. This research study is looking for 40 people who are receiving platelet-rich plasma therapy for a tendon or muscle injury. The study involves collecting seven blood samples (2 teaspoons each) from each patient, before and after the PRP treatment. Blood samples may be donated at any location of the patient's choosing, and participants will be paid for their time.

Official Title

Effect of Intramuscular and Intratendinous Platelet-Rich Plasma Injections on Systemic Concentrations of Performance-Enhancing Growth Factors

Eligibility Criteria

Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - Male and female patients 18-50 years old, receiving ultrasound-guided intratendinous or intramuscular PRP injections
Exclusion Criteria:
  1. - History of cancer, diabetes, hormone-replacement therapy, or abnormal nutritional habits. - Contraindications for PRP therapy itself: - preexisting coagulation defects including thrombocytopenia - hypofibrinogenemia - anticoagulation medications - hypersensitivity to bovine products, which may be used for platelet activation.

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Amy S Wasterlain