Perfusion CT as a Predictor of Treatment Response in Patients With Rectal Cancer

Trial ID or NCT#

NCT01460641

Status

not recruiting iconNOT RECRUITING

Purpose

A research study of rectal cancer perfusion (how blood flows to the rectum over time). We hope to learn whether perfusion characteristics of rectal masses may be predictive of response to treatment and whether rectal perfusion characteristics can be used to follow response to treatment.

Official Title

Perfusion CT as a Predictor of Treatment Response in Patients With Rectal Cancer

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. * Patients with suspected or biopsy-proven, locally advanced rectal cancer will be eligible for enrollment.* Patients must be 18 years or older. Patients must not be pregnant and, if of child-bearing age, must take precautions not to become pregnant.* No life expectancy restrictions.* ECOG and Karnofsky Performance Status will not be employed.* Patients with renal failure are ineligible for this study (GFR must be \> 60)* Ability to understand and willingness to sign a written informed consent document.
Exclusion Criteria:
  1. * Patients who have undergone prior treatment for rectal cancer are ineligible for enrollment.* No restrictions regarding use of other investigational agents.* Patients with severe contrast allergy are ineligible.* Patients who are pregnant or are trying to become pregnant are excluded from this study.* Patients who are cancer survivors or HIV-positive will not be excluded.
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Investigator(s)

Subhas Banerjee
Subhas Banerjee
Gastroenterologist, Therapeutic endoscopy specialist, Biliary specialist, Endoscopic ultrasound specialist
Professor of Medicine (Gastroenterology and Hepatology)
Daniel Rubin
Uri Ladabaum
Uri Ladabaum
Gastroenterologist, Geneticist, Cancer geneticist, General gastroenterologist
Professor of Medicine (Gastroenterology and Hepatology)
Andrew A. Shelton, MD, FACS, FACRS
Andrew A. Shelton, MD, FACS, FACRS
Colorectal surgeon
Clinical Professor, Surgery - General Surgery
R Brooke Jeffrey
George A. Fisher Jr.
George A. Fisher Jr.
Medical oncologist, Gastrointestinal specialist
Colleen Haas Chair in the School of Medicine
Teri A Longacre
Teri A Longacre
Pathologist, Surgical pathologist, Immunodiagnosis pathologist
Richard L. Kempson, MD, Professor in Surgical Pathology
Dominik Fleischmann
Dominik Fleischmann
Radiologist, Cardiologist
Professor of Radiology (Cardiovascular Imaging)

Contact us to find out if this trial is right for you.

Contact

Laura Gable
650-736-0798

View on ClinicalTrials.gov