Platelet Rich Plasma for Patients With Recurrent Implantation Failure

Trial ID or NCT#

NCT03379649

Status

not recruiting iconNOT RECRUITING

Purpose

Patients with recurrent implantation failure are among the most difficult patients to treat, with no proven standard treatment. Platelet rich plasma stimulates cellular processes involved in endometrial regeneration, and in a small case series has shown efficacy for this patient population. We hope to conduct a randomized controlled pilot study to determine whether PRP is indeed an effective treatment for recurrent implantation failure.

Official Title

Platelet Rich Plasma for Patients With Recurrent Implantation Failure: A Prospective Randomized Pilot Study

Eligibility Criteria

Ages Eligible for Study: 18 Years to 45 Years
Sexes Eligible for Study: Female
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. - All women who have undergone 3 or more embryo (blastocyst stage) transfers without establishing a clinical pregnancy or 2 or more euploid embryo transfers without establishing a clinical pregnancy, aged 18 - 45, with a normal uterine cavity established within 12 months by hysteroscopy or saline infusion sonogram, planning in vitro fertilization with an embryo transfer at Stanford Fertility and Reproductive Health. The planned transfer must consist of any of the following: a PGS proven euploid embryo, a good quality blastocyst from a patient younger than 37, or a donor oocyte blastocyst.
Exclusion Criteria:
  1. - Abnormal uterine cavity, planning in vitro fertilization with use of a gestational carrier. patients enrolled in other experimental interventions for RIF will be excluded. Patients with only poor quality or cleavage stage embryos.
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Investigator(s)

Lusine Aghajanova, M.D., Ph.D.
Fertility specialist, Obstetrician and Gynecologist (OB-GYN)
Clinical Associate Professor, Obstetrics & Gynecology - Reproductive Endocrinology & Infertility
Ruth Lathi, M.D.
Ruth Lathi, M.D.
Obstetrician and Gynecologist (OB-GYN), Fertility specialist
Professor of Obstetrics and Gynecology (Reproductive Endocrinology and Infertility)

Contact us to find out if this trial is right for you.

Contact

Jonathan D Kort, M.D.
650-498-7911

View on ClinicalTrials.gov