PET/MRI in the Diagnosis of Chronic Pain

Trial ID or NCT#

NCT03556137

Status

recruiting iconRECRUITING

Purpose

Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using \[18F\]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of \[18F\]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain.

Official Title

Use of [18F]FTC-146 PET/MRI in the Diagnosis of Chronic Pain

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: ALL
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. Healthy Volunteers:
    1. 1. At least 18 years old.2. Covid Vaccination status: Vaccinated or unvaccinated subjects who received a negative test result from the Covid test within 72 hours of the scan.
  2. Pain Patients:
    1. 1. At least 18 years old.2. Chronic pain (nociceptive, neuropathic or mixed pain) lasting greater than 2 months.3. Pain level of at least 4/10 on a 0-10 Comparative Pain Scale.4. Covid Vaccination status: Vaccinated or unvaccinated subjects who received a negative test result from the Covid test within 72 hours of the scan.
Exclusion Criteria:
  1. Healthy Volunteers:
    1. 1. Pain2. Pain Medication3. MRI incompatible4. Pregnant or nursing5. Non-English speaker6. Claustrophobic
  2. Pain Patients:
    1. 1. MRI incompatible2. Pregnant or nursing3. Non-English speaker4. Claustrophobic
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Investigator(s)

Anand Veeravagu, MD, FAANS, FACS
Anand Veeravagu, MD, FAANS, FACS
Spine neurosurgeon, Neurosurgeon
Associate Professor of Neurosurgery and, by courtesy, of Orthopaedic Surgery

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Contact

Adrian Valladarez, BA

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View on ClinicalTrials.gov