PET/MRI in the Diagnosis of Chronic Pain
Trial ID or NCT#
Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using [18F]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain.
Use of [18F]FTC-146 PET/MRI in the Diagnosis of Chronic Pain
- Healthy Volunteers: 1. At least 18 years old. Pain Patients: 1. At least 18 years old. 2. Chronic pain (nociceptive, neuropathic or mixed pain) lasting greater than 2 months. 3. Pain level of at least 4/10 on a 0-10 Comparative Pain Scale.
- Healthy Volunteers: 1. Pain 2. Pain Medication 3. MRI incompatible 4. Pregnant or nursing 5. Non-English speaker Pain Patients: 1. MRI incompatible 2. Pregnant or nursing 3. Non-English speaker
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Peter W Cipriano, BA
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