Trial ID or NCT#





This study is designed to evaluate the safety and effectiveness of an investigational procedure for treating people with treatment resistant bipolar depression. Precise dose delivery of radiation to the predetermined targets in the brain will be accomplished with known Cyberknife stereotactive radiosurgery methods.. This technology is considered to be noninvasive (does not physically invade your body). We will be studying if the Cyberknife influences the sensitivity of certain nerves of your brain. Although many clinical treatments for psychiatric conditions have been done using stereotactive radiosurgery, the present study is experimental, because we are seeking to use more moderate doses of radiation that are intended not to destroy any brain cells, but to normalize or modulate their function.

Official Title

Radiosurgical Neuromodulation for Refractory Depression

Eligibility Criteria

Ages Eligible for Study: 22 Years to 65 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No


John R. Adler, MD
Hugh Brent Solvason PhD MD
Clinical Professor, Psychiatry and Behavioral Sciences
Charles DeBattista
Professor of Psychiatry and Behavioral Sciences (General Psychiatry and Psychology - Adult) at the Stanford University Medical Center

Contact us to find out if this trial is right for you.


Jessica Hawkins
(650) 723-8323