Study of Pain Processing in Subjects Suffering From Obstructive Sleep Apnea

Trial ID or NCT#

NCT00672737

Status

not recruiting iconNOT RECRUITING

Purpose

We would like to test the effect of opioid medication on pain sensitivity in subjects who have been diagnosed with a sleep disorder called Obstructive Sleep Apnea (OSA) compared to other subjects without OSA. Patients with OSA may have an altered sensitivity to the sedative, analgesic, and respiratory depressant effects of opioids.

Official Title

Experimental Pain Processing and Autonomic Function in Subjects Suffering From Obstructive Sleep Apnea

Eligibility Criteria

Ages Eligible for Study: 18 Years to 55 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: Yes
Inclusion Criteria:
  1. 1. Male 2 .18 - 55 years of age 3. Body mass index (BMI) lower or equal to 30 kg/m2 4. Absence of severe systemic disease that results in functional limitations (i.e. poorly controlled hypertension, angina pectoris, prior myocardial infarction, pulmonary disease that limits activity) 5.Subjects must be able to comprehend spoken and written English
Exclusion Criteria:
  1. 1. Major psychiatric, neurological, or neuromuscular disorder 2. Known diabetes mellitus or thyroid disease 3. Allergy to study medication (remifentanil) 4. History of addiction 5. Alcohol consumption which exceeds 2 drinks per day and /or drug abuse. 6. Chronic or acute use of opioids, or other medications affecting the CNS.
View All Criteria
Show Less

Investigator(s)

Anthony G. Doufas, M.D., Ph.D.
Anthony G. Doufas, M.D., Ph.D.
Anesthesiologist
Professor of Anesthesiology, Perioperative and Pain Medicine

View on ClinicalTrials.gov