Trial ID or NCT#



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This research study explores whether a beta-blocker can prevent a person from becoming more sensitive to pain after administration of an opioid. Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.

Official Title

Effect of Beta Blockade on Opioid-Induced Hyperalgesia in Humans

Eligibility Criteria

Ages Eligible for Study: 18 Years to 45 Years
Sexes Eligible for Study: Male
Accepts Healthy Volunteers: Yes


Lawrence Chu, MD, MS
Lawrence Chu, MD, MS
Professor of Anesthesiology, Perioperative and Pain Medicine at the Stanford University Medical Center

Contact us to find out if this trial is right for you.


Larry Chu, MD, MS
(650) 723-5439