The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.

Trial ID or NCT#

NCT01927406

Status

not recruiting iconNOT RECRUITING

Purpose

The purpose of this study is to evaluate the potential secondary beneficial effect of prostaglandin analogues (PA) treatment in thyroid eye disease (TED) patients. This study aims to determine if PA would change the course of the orbitopathy in TED patients by altering the progression of the common features of TED, including fatty hypertrophy, proptosis, eyelid retraction and optic nerve compression. The eyes with thyroid eye disease and elevated intraocular pressure will be randomised to the PA treatment and the other eye will serve as a control eye and will be treated with Timolol.

Official Title

The Secondary Beneficial Effects of Prostaglandin Analog Treatment in Thyroid Eye Disease Patients.

Eligibility Criteria

Ages Eligible for Study: Older than 18 Years
Sexes Eligible for Study: All
Accepts Healthy Volunteers: No
Inclusion Criteria:
  1. - mild or moderate to severe thyroid eye disease in one or both eyes - age > 18 years - informed consent - intraocular pressure > 21 mmHg or glaucoma suspect or glaucoma diagnosed in one or both eyes - not on current prostaglandin analog intraocular pressure lowering therapy
Exclusion Criteria:
  1. - sight threatening thyroid eye disease - children < 18 years old - patients that are not compliant with treatment or follow-up - patients already on prostaglandin analog treatment - patients that undergo cosmetic periocular procedures during the study will be excluded from further follow up - patients that cannot tolerate prostaglandin analog treatment. - patients with bilateral thyroid eye disease and elevated intraocular pressures that cannot tolerate treatment with timolol or an alternative intraocular pressure lowering medication such as trusopt, combigan, cosopt.

Investigator(s)

Andrea Lora Kossler, MD, FACS
Andrea Lora Kossler, MD, FACS
Ophthalmologist, Ophthalmic plastic and reconstructive surgeon
Assoc Professor of Ophthalmology

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Contact

Barbara Bartlett
650-724-9259